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The sodium salt occurs as a white, slightly bitter powder which is freely soluble rein water and alcohol but practically insoluble in benzene and ether.

The barbiturates are nonselective central nervous Anlage depressants which are primarily used as sedative hypnotics and also anticonvulsants in subhypnotic doses.

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Phenobarbital has been shown to shorten the half-life of doxycycline for as long as 2 weeks after barbiturate therapy is discontinued. This mechanism is probably through the induction of hepatic microsomal enzymes that metabolize the antibiotic.

The more lipid soluble the barbiturate, the more rapidly it penetrates all tissues of the body. Barbiturates are bound to plasma and tissue proteins to a varying degree with the degree of binding increasing directly as a function of lipid solubility.

Phenobarbital sodium is carcinogenic in mice and rats after lifetime administration. Rein mice, it produced benign and malignant liver cell tumors. In rats, benign liver cell tumors were observed very late hinein life.

Most reports of clinically significant drug interactions occurring with the barbiturates have involved phenobarbital. However, the application of these data to other barbiturates appears valid and warrants serial blood level determinations of the Bedeutend drugs when there are multiple therapies.

Barbiturates are absorbed hinein varying degrees following oral, rectal, or parenteral administration. The salts are more rapidly absorbed than are the acids.

Should signs of withdrawal occur on the first day of treatment, a loading dose of 100 to 200 mg of phenobarbital may Beryllium administered IM rein addition to the oral dose. After stabilization on phenobarbital, the total daily dose is decreased by 30 mg a day as long as withdrawal is proceeding smoothly. A modification of this regimen involves initiating treatment at the patient's regular dosage level and decreasing the daily dosage by 10 percent if tolerated by the patient.

4. Compatible with death hinein aged or ill persons or in presence of obstructed airway, other toxic agents, or exposure to cold.

There are no data on pregnancy exposures rein primates corresponding to periods prior to the third trimester hinein humans.

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Phenobarbital appears to interfere with the absorption of orally administered griseofulvin, thus decreasing its blood level.

There has been no concrete evidence to show whether men or women suffer more from acne. But young men are more prone to the different forms of acne than women.